For an oocyte to get Completely ready for fertilization and progress into an embryo, the correct list of genes should be turned on. Namekawa suspected this pre-programming of the oocyte genome transpires in many phases — the initial 1 beginning throughout the time a feminine is born. He believed that chromatin remodeling proteins did Significantly of the perform, by shifting spools around.

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Utilizing the GCRLE grant, Munakata and Namekawa will glance far more closely at how oocytes are genomically primed and saved for afterwards use. They may examine the position of a chromatin remodeler in oocyte survival and fertility.

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